Loss of regulation of lipogenesis in the Zucker diabetic (ZDF) rat, II: Changes in stearate and oleate synthesis
نویسندگان
چکیده
Department of Pediatrics, Research and Education Institute Harbor-UCLA Medical Center, Torrance, CA 90502. 1. Supported by a grant from the NIH (DK56090-A1) and American Diabetes Association (ADA). The GC/MS Facility is supported by PHS grants P01-CA42710 to the UCLA Clinical Nutrition Research Unit, Stable Isotope Core and M01-RR00425 to the General Clinical Research Center. 2. To whom correspondence should be addressed. W-N Paul Lee Harbor-UCLA Medical Center, RB1 1124 W. Carson St., Torrance, California 90502. Tel: 310-222-6729 Fax: 310-533-0627 e-mail: [email protected] Running Title: Chain elongation and desaturation in adaptation to increased dietary Fat/CHO ratio.
منابع مشابه
Loss of regulation of lipogenesis in the Zucker diabetic rat. II. Changes in stearate and oleate synthesis.
De novo lipogenesis and dietary fat uptake are two major sources of fatty acid deposits in fat of obese animals. To determine the relative contribution of fatty acids from these two sources in obesity, we have determined the distribution of c16 and c18 fatty acids of triglycerides in plasma, liver, and epididymal fat pad of Zucker diabetic fatty (ZDF) rats and their lean littermates (ZL) under ...
متن کاملLoss of regulation of lipogenesis in the Zucker diabetic (ZDF) rat.
We present here a study on the role of leptin in the regulation of lipogenesis by examining the effect of dietary macronutrient composition on lipogenesis in the leptin receptor-defective Zucker diabetic fatty rat (ZDF) and its lean litter mate (ZL). Animals were pair fed two isocaloric diets differing in their fat-to-carbohydrate ratio providing 10 and 30% energy as fat. Lipogenesis was measur...
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